Browsing by Author "Hidalgo Tapia, María Cecilia"

Now showing items 1-10 of 10

    • Activation of calcium channels in sarcoplasmic reticulum from frog muscle by nanomolar concentrations of ryanodine 
      Bull, Alan; Marengo, Juan José; Suárez Isla, Benjamín; Donoso P., Gonzalo; Sutko, J. L.; Hidalgo Tapia, María Cecilia (1989)
      Sarcoplasmic reticulum vesicles isolated from fast-twitch frog skeletal muscle presented two classes of binding sites for ryanodine, one of high affinity (Kd1 = 1.7 nM, Bmax1 = 3.3 pmol per mg) and a second class with lower ...
    • Calcium microdomains and gene expression in neurons and skeletal muscle cells 
      Carrasco Friz, María Angélica; Hidalgo Tapia, María Cecilia (CHURCHILL LIVINGSTONE, 2006-12)
      Neurons generate particular calcium microdomains in response to different stimuli. Calcium microdomains have a central role in a variety of neuronal functions. In particular, calcium microdomains participate in long-lasting ...
    • Cholesterol removal from adult skeletal muscle impairs excitation-contraction coupling and aging reduces ... 
      Barrientos Briones, Genaro; Llanos Vidal, Paola; Hidalgo Tapia, Jorge; Bolaños, Pura; Caputo, Carlo; Riquelme, Alexander; Sánchez, Gina; Quest, Andrew F. G.; Hidalgo Tapia, María Cecilia (Frontiers Research Foundation, 2015)
      Cholesterol and caveolin are integral membrane components that modulate the function/location of many cellular proteins. Skeletal muscle fibers, which have unusually high cholesterol levels in transverse tubules, express ...
    • Glucose-Dependent Insulin Secretion in Pancreatic beta-Cell Islets from Male Rats Requires Ca2+ Release via ... 
      Llanos Vidal, Paola; Contreras Ferrat, Ariel Eduardo; Barrientos Briones, Genaro; Valencia, Marco; Mears, David; Hidalgo Tapia, María Cecilia (Public Library Science, 2015)
      Glucose-stimulated insulin secretion (GSIS) from pancreatic beta-cells requires an increase in intracellular free Ca2+ concentration ([Ca2+]). Glucose uptake into beta-cells promotes Ca2+ influx and reactive oxygen species ...
    • Inhibitory ryanodine prevents ryanodine receptor-mediated Ca2+ release without affecting endoplasmic reticulum ... 
      Adasme, Tatiana; Paula-Lima, Andrea; Hidalgo Tapia, María Cecilia (Academic Press, 2015)
      Ryanodine is a cell permeant plant alkaloid that binds selectively and with high affinity to ryanodine receptor (RyR) Ca2þ release channels. Sub-micromolar ryanodine concentrations activate RyR channels while micromolar ...
    • Insulin elicits a ROS-activated and an IP3-dependent Ca2+ release, which both impinge on GLUT4 translocation 
      Contreras Ferrat, Ariel Eduardo; Llanos Vidal, Paola; Vásquez, César; Espinosa, Alejandra; Osorio Fuentealba, César; Arias Calderón, Manuel; Lavandero González, Sergio; Klip, Amira; Hidalgo Tapia, María Cecilia; Jaimovich Pérez, Enrique (The Company of Biologists Ltd, 2014)
      Insulin signaling includes generation of low levels of H2O2; however, its origin and contribution to insulin-stimulated glucose transport are unknown. We tested the impact of H2O2 on insulin-dependent glucose transport ...
    • Iron Mediates N-Methyl-D-aspartate Receptor-dependent Stimulation of Calcium-induced Pathways and Hippocampal ... 
      Muñoz, Pablo; Humeres, Alexis; Elgueta, Claudio; Kirkwood, Alfredo; Hidalgo Tapia, María Cecilia; Núñez González, Marco (AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2011-04-15)
      Iron deficiency hinders hippocampus-dependent learning processes and impairs cognitive performance, but current knowledge on the molecular mechanisms underlying the unique role of iron in neuronal function is sparse. Here, ...
    • Ryanodine receptor-mediated Ca2+ release underlies iron-induced mitocondrial fission and stimulates ... 
      San Martín Rovirosa, Carol; Paula Lima, Andrea; García, Alejandra; Barattini, Pablo; Hartel, Steffen; Núñez González, Marco; Hidalgo Tapia, María Cecilia (2014)
      Mounting evidence indicates that iron accumulation impairs brain function. We have reported previously that addition of sub-lethal concentrations of iron to primary hippocampal neurons produces Ca2+ signals and promotes ...
    • Signal transduction and gene expression regulated by calcium release from internal stores in excitable cells 
      Carrasco Friz, María Angélica; Jaimovich Pérez, Enrique; Kemmerling Weis, Ulrike; Hidalgo Tapia, María Cecilia (SOCIEDAD BIOLOGIA CHILE, 2004)
      Calcium regulation of several transcription factors involves different calcium-dependent signaling cascades and engages cytoplasmic as well as nuclear calcium signals. The study of the specific sources of calcium signals ...
    • The transcription factor MEF2C mediates cardiomyocyte hypertrophy induced by IGF-1 signaling 
      Muñoz, Juan Pablo; Collao, Andrés; Chiong Lay, Mario; Maldonado Vera, Carola Patricia; Adasme, Tatiana; Carrasco Alarcón, Loreto del Pilar; Ocaranza Osses, Paula; Bravo Méndez, Roberto; González, Leticia; Díaz Araya, Guillermo; Hidalgo Tapia, María Cecilia; Lavandero González, Sergio (ACADEMIC PRESS INC ELSEVIER SCIENCE, 2009-10-09)
      Myocyte enhancer factor 2C (MEF2C) plays an important role in cardiovascular development and is a key transcription factor for cardiac hypertrophy. Here, we describe MEF2C regulation by insulin-like growth factor-1 (IGF-1) ...